Search results for "grupo de ascendencia continental europea"

showing 2 items of 2 documents

The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis.

2013

Systemic sclerosis (SSc) is a fibrotic autoimmune disease in which the genetic component plays an important role. One of the strongest SSc association signals outside the human leukocyte antigen (HLA) region corresponds to interferon (IFN) regulatory factor 5 (IRF5), a major regulator of the type I IFN pathway. In this study we aimed to evaluate whether three different haplotypic blocks within this locus, which have been shown to alter the protein function influencing systemic lupus erythematosus (SLE) susceptibility, are involved in SSc susceptibility and clinical phenotypes. For that purpose, we genotyped one representative single-nucleotide polymorphism (SNP) of each block (rs10488631, r…

MaleLinkage disequilibrium:Phenomena and Processes::Genetic Phenomena::Phenotype [Medical Subject Headings]Polimorfismo de nucleótido simpleSLElcsh:MedicineAutoimmunityGenome-wide association studyLinkage DisequilibriumScleroderma:Phenomena and Processes::Genetic Phenomena::Genotype::Haplotypes [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Gene Frequency:Named Groups::Persons::Population Groups::Continental Population Groups::European Continental Ancestry Group [Medical Subject Headings]Risk FactorsIRF5Genetics of the Immune SystemLupus Erythematosus Systemic:Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Scleroderma Systemic [Medical Subject Headings]skin and connective tissue diseaseslcsh:ScienceMultidisciplinary:Diseases::Immune System Diseases::Autoimmune Diseases::Lupus Erythematosus Systemic [Medical Subject Headings]Predisposición genética a la enfermedad:Phenomena and Processes::Genetic Phenomena::Genetic Linkage::Linkage Disequilibrium [Medical Subject Headings]:Phenomena and Processes::Genetic Phenomena::Genotype::Genetic Predisposition to Disease [Medical Subject Headings]PhenotypeInterferon Regulatory FactorsSYSTEMIC SCLEROSISMedicineEvaluation of complex medical interventions Auto-immunity transplantation and immunotherapy [NCEBP 2]FemaleIRF5; SLE; TYPE I INTERFERON; SYSTEMIC SCLEROSISHaplotiposResearch ArticleFactores de riesgoImmunology:Chemicals and Drugs::Amino Acids Peptides and Proteins::Peptides::Intracellular Signaling Peptides and Proteins::Adaptor Proteins Signal Transducing::Interferon Regulatory Factors [Medical Subject Headings]:Check Tags::Male [Medical Subject Headings]:Health Care::Environment and Public Health::Public Health::Epidemiologic Factors::Causality::Risk Factors [Medical Subject Headings]Single-nucleotide polymorphismHuman leukocyte antigenBiologyPolymorphism Single NucleotideWhite PeopleAutoimmune DiseasesRheumatologyLupus eritematoso sistémicoGeneticsHumansGenetic Predisposition to DiseaseGrupo de ascendencia continental europeaAlleleBiologyAllele frequencyAllelesGenetic Association Studies:Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles [Medical Subject Headings]Scleroderma SystemicHaplotypelcsh:R:Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genetic Loci [Medical Subject Headings]Human Genetics:Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism Genetic [Medical Subject Headings]Factores reguladores del interferónHaplotypesDesequilibrio de ligamiento:Check Tags::Female [Medical Subject Headings]Genetic LociTYPE I INTERFERONGenetics of DiseaseImmunologyGenetic PolymorphismClinical Immunologylcsh:Q:Phenomena and Processes::Genetic Phenomena::Gene Frequency [Medical Subject Headings]Population GeneticsIRF5PLoS ONE
researchProduct

National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio : a pooled analy…

2020

Artículo con numerosos autores. Sólo quedan reflejados el primero, los pertenecientes a la UAM y el colectivo

Malegupo de ascendencia continental asiáticaSettore MED/09 - Medicina InternaTotal Cholesterol ; Ldl Cholesterol ; Hdl Cholesterol ; Blood Lipids ; Multi-country StudyEpidemiologykolesterolihumanosBlood lipidsBLOOD-PRESSURE030204 cardiovascular system & hematologytriglicéridoschemistry.chemical_compound0302 clinical medicineHigh-density lipoproteinHDL cholesterolEpidemiologyMedicine and Health SciencesCARDIOVASCULAR RISK-FACTORSMedicine030212 general & internal medicinemediana edadlípidosPublic Environmental & Occupational Health2. Zero hungerancianoeducation.field_of_studyAge FactorsPublic Health Global Health Social Medicine and EpidemiologyGeneral MedicineMiddle Agedcolesteroladultokansainvälinen vertailuLipids3142 Public health care science environmental and occupational health3. Good healthEuropeCholesterolPopulation SurveillanceLDL cholesterolSERUM-LIPIDSFemalelipids (amino acids peptides and proteins)Life Sciences & BiomedicineAdultAsian Continental Ancestry GroupCanadaHDL cholesterol; LDL cholesterol; Total cholesterol; blood lipids; multi-country studymedicine.medical_specialtyAsiaMedicinaEuropean Continental Ancestry GroupPopulationNursingHDL-kolesteroliWhite PeopleDIETARY-FAT03 medical and health sciencesSex FactorsAsian Peoplekansanterveysvigilancia de la poblaciónTotal cholesterolHumansCORONARY-HEART-DISEASEmulti-country studyddc:610LDL-kolesteroliTotal cholesteroleducationTriglyceridesMETAANALYSISAgedINDIVIDUAL DATAScience & Technologyblood lipidsbusiness.industryCholesterolOmvårdnadblood lipidCholesterol HDLEcological studynutritional and metabolic diseasesCholesterol LDLUnited StatesFolkhälsovetenskap global hälsa socialmedicin och epidemiologiAdult; Age Factors; Aged; Asia; Asian Continental Ancestry Group; Canada; Cholesterol/blood; Cholesterol HDL; Cholesterol LDL; Europe; European Continental Ancestry Group; Female; Humans; Lipids/blood; Male; Middle Aged; Population Surveillance/methods; Sex Factors; Triglycerides/blood; United States; HDL cholesterol; LDL cholesterol; Total cholesterol; blood lipids; multi-country studychemistryWORLDWIDE TRENDSMulti-country study ; Total cholesterol ; HDL cholesterol ; LDL cholesterol ; Blood lipidsgrupo de ascendencia continental europeabusinessHIGH-DENSITY-LIPOPROTEIN[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyDemographyLipoprotein
researchProduct